Thermo Fisher Scientific CD4 Monoclonal Antibody (OTI9C1), TrueMAB

Applications

Tested Dilution

• Western Blot (WB): 1:1,000–1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of about 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

The CD4 antigen is involved in recognition of MHC class II molecules and acts as a co-receptor for HIV.
CD4 is primarily expressed in T helper cells but can also be found in monocytes, macrophages, and dendritic cells.
Tissue expression includes thymus, lymph nodes, tonsils, spleen, and certain regions of brain and gut.
CD4 functions in early T-cell activation via association with the T-cell receptor complex and kinase Lck, and may mediate neuronal damage in infectious or immune-mediated CNS diseases.
Multiple alternatively spliced transcripts have been identified (RefSeq, July 2017).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.