Thermo Fisher Scientific Protein C Recombinant Mouse Monoclonal Antibody (HPC-4)
Recombinant mouse monoclonal antibody (clone HPC-4) targeting human Protein C. Validated for WB, ICC/IF, ELISA, IA, and AP. Recognizes activation peptide region, not activated Protein C. Cross-reactive with baboon Protein C. Supplied in PBS with 0.02% ...
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Applications and Tested Dilutions
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | Assay-dependent | |
| Immunocytochemistry (ICC/IF) | 1:200 | |
| ELISA | 10 µg/mL | |
| Inhibition Assays (IA) | Assay-dependent | |
| Affinity Purification (AP) | Assay-dependent |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Baboon, Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | HPC-4 |
| Immunogen | Raised by immunizing mice with human Protein C |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
This antibody specifically binds to a twelve amino acid peptide sequence (EDQVDPRLIDGK) in the activation region of Protein C, spanning the thrombin cleavage site. It does not react with activated Protein C. Cross-reactive with baboon Protein C, but not with bovine or mouse Protein C.
Target Information
Protein C is a vitamin K-dependent plasma glycoprotein activated by the thrombin-thrombomodulin complex. The active form contains a serine protease domain that degrades activated coagulation factors V and VIII, thereby inhibiting blood coagulation. It is produced in the liver and consists of two polypeptide chains. The 62 kDa proenzyme is activated to a 55 kDa enzyme. Normal plasma concentrations are approximately 1–3 ng/mL for the active form and ~3 µg/mL for the proenzyme. Mutations in the Protein C gene are associated with thrombophilia due to Protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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