Thermo Fisher Scientific ORM2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:3,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total ORM2.

Target Information

AGP (α1-acid Glycoprotein) is an acute phase plasma protein synthesized by the liver. It regulates interactions between blood cells and endothelial cells and, together with haptoglobin and C-reactive protein, mediates cell extravasation during infection and inflammation. Expression is induced by bacterial lipopolysaccharides.
AGP binds basic drugs with high affinity and low capacity at physiological pH. In human plasma, AGP levels are typically 0.5–1.4 mg/mL but increase during acute inflammation, making it a useful marker for inflammatory conditions.
Multiple AGP genes exist, including AGP-1, AGP-2, AGP-3, and AGP-8. AGP-1 and AGP-2 contain five and six potential N-glycosylation sites, respectively. Abnormal expression of AGP-1 is linked to sarcoidosis and other immunogenetic diseases, while mutations in AGP-2 are associated with various carcinomas.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.