Thermo Fisher Scientific KIF3A Polyclonal Antibody
KIF3A 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC(P), ICC/IF에 사용 가능. 인간, 마우스, 랫트 반응성. 고순도 친화 크로마토그래피 정제, 1 mg/mL 농도. 세포 내 수송 및 신경발생 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human KIF3A (Accession Q9Y496), corresponding to amino acid residues E605–Y655 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852417 |
Product Specific Information
Antibody detects endogenous levels of total KIF3A.
Target Information
Kinesins are microtubule-dependent motor proteins responsible for the distribution of organelles, vesicles, and macromolecular complexes throughout the cell. Members of the heterotrimeric kinesin II family, including KIF3A, B, and C, mediate anterograde transport of membrane-bound organelles in neurons and melanosomes, facilitate transport between the endoplasmic reticulum and Golgi, and support protein transport within cilia and flagella for morphogenesis.
KIF3A may influence neurogenesis and left-right axis determination during embryonic development. Loss of KIF3A function in mouse photoreceptors leads to apoptotic cell death, indicating that kinesin II-mediated transport is essential for proper cell fate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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