Thermo Fisher Scientific IFN beta Monoclonal Antibody (A1 (IFNb)), FITC, eBioscience
휴먼 IFN-β를 인식하는 단클론 항체로, FITC 형광 표지되어 Flow cytometry, ELISA, Western blot 등 다양한 분석에 활용 가능. 자연형 및 재조합형 IFN-β1a/β1b를 중화하며, 4°C 암소 보관. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-Dependent | - |
| Flow Cytometry (Flow) | - | 1 publication |
| ELISA | Assay-Dependent | - |
| Functional Assay | Assay-Dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | A1 (IFNb) |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | TBS, pH 7.2–7.4, with 1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11220279 |
Additional Formats
- Unconjugated (BMS1044)
- Biotin (BMS1044BT)
- Functional Grade (16-9978-81)
- Custom conjugation available upon request
Product Specific Information
The IFNb/A1 clone recognizes natural human IFN-beta as well as recombinant IFN-beta1a and IFN-beta1b. It is capable of neutralizing IFN-beta activity.
Interferon beta is synthesized and secreted by fibroblasts and various other cell types in response to pathogens. Binding of IFN-beta to type I interferon receptors induces upregulation of IRF-7 and activation of RNase L. IRF-7 enhances IFN-beta production through positive feedback, while RNase L cleaves viral and cellular single-stranded mRNA, restricting viral replication and spread.
Applications Tested: ELISA, Neutralization tests, Western Blotting
Excitation: 488 nm
Emission: 520 nm
Laser: Blue Laser
Target Information
Type I Interferons (IFN-alpha/beta) are primarily produced in response to viral infection by Natural IFN-producing cells (IPCs) as part of the host immune defense. IFNs can also inhibit tumor development. IFN-beta binding activates tyrosine kinases Jak1 and Tyk2, leading to phosphorylation of STAT transcription factors and subsequent gene expression associated with immune responses. Toll-like receptors (TLRs) also stimulate IFN-beta production. Clinically, IFN-beta is used in the treatment of tumors, infections, and multiple sclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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