Thermo Fisher Scientific IFN beta Monoclonal Antibody (A1 (IFNb)), eBioscience

Applications and Tested Dilution

Product Specifications

Additional Formats

• Biotin
• FITC
• Functional Grade
• Request custom conjugation

Product Specific Information

The IFNb/A1 clone recognizes natural human IFN-beta and recombinant forms beta1a and beta1b. It is capable of neutralizing IFN-beta.

Interferon beta is synthesized and secreted by fibroblasts and other cell types in response to pathogens. Binding to type I interferon receptors induces upregulation of IRF-7 and activation of RNase L. IRF-7 enhances IFN-beta production, while RNase L cleaves viral and cellular single-stranded mRNA to limit viral replication and spread.

Applications Tested: ELISA, Neutralization tests, Western Blotting.

Target Information

Type I Interferons (IFN-alpha/beta) are produced mainly in response to viral infection by natural IFN-producing cells (IPCs) as part of the host immune defense. IFNs can also inhibit tumor development. IFN-beta binding activates tyrosine kinases Jak1 and Tyk2, leading to phosphorylation of STAT transcription factors and induction of immune response genes. Toll-like receptors (TLRs) also stimulate IFN-beta production. Clinically, IFN-beta is used in the treatment of tumors, infections, and multiple sclerosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.