Thermo Fisher Scientific IFN beta Monoclonal Antibody (A1 (IFNb)), eBioscience
인간 IFN-beta를 인식하고 중화 가능한 단일클론 항체. Western blot, ELISA, 기능적 분석에 사용 가능. 비결합형 액상 포맷, 1 mg/mL 농도. 연구용으로 바이러스 감염 및 면역 반응 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-Dependent |
| ELISA | Assay-Dependent |
| Functional Assay | Assay-Dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | A1 (IFNb) |
| Immunogen | Recombinant Human IFN beta |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2–7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10598059 |
Additional Formats
Product Specific Information
The IFNb/A1 clone recognizes natural human IFN-beta and recombinant forms beta1a and beta1b. It is capable of neutralizing IFN-beta.
Interferon beta is synthesized and secreted by fibroblasts and other cell types in response to pathogens. Binding to type I interferon receptors induces upregulation of IRF-7 and activation of RNase L. IRF-7 enhances IFN-beta production, while RNase L cleaves viral and cellular single-stranded mRNA to limit viral replication and spread.
Applications Tested: ELISA, Neutralization tests, Western Blotting.
Target Information
Type I Interferons (IFN-alpha/beta) are produced mainly in response to viral infection by natural IFN-producing cells (IPCs) as part of the host immune defense. IFNs can also inhibit tumor development. IFN-beta binding activates tyrosine kinases Jak1 and Tyk2, leading to phosphorylation of STAT transcription factors and induction of immune response genes. Toll-like receptors (TLRs) also stimulate IFN-beta production. Clinically, IFN-beta is used in the treatment of tumors, infections, and multiple sclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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