Thermo Fisher Scientific IFN beta Monoclonal Antibody (A1 (IFNb)), Biotin, eBioscience

Applications and Tested Dilutions

Product Specifications

Available Formats

• Unconjugated
• FITC
• Functional Grade
• Request custom conjugation

Product Specific Information

The IFNb/A1 clone recognizes natural human IFN-beta and recombinant IFN-beta1a and IFN-beta1b. It is capable of neutralizing IFN-beta.

Interferon beta is synthesized and secreted by fibroblasts and many other cell types in response to pathogens. IFN-beta binding to type I interferon receptors induces the upregulation of IRF-7 and activation of RNase L. IRF-7 can exert a positive feedback on IFN-beta production. RNase L cleaves both viral and cellular single-stranded mRNA, thereby limiting viral replication and dissemination.

Applications Tested: ELISA, Neutralization tests, Western Blotting.

Target Information

Type I Interferons (IFN-alpha/beta) are produced primarily in response to viral infection by Natural IFN-producing cells (IPCs) as part of the host immune response. IFNs can also inhibit the development of tumors. IFN-beta binding results in activation of the tyrosine kinases Jak1 and Tyk2, phosphorylation of STAT family transcription factors, and transcription of immune response genes. Several members of the Toll-like receptor (TLR) family also stimulate IFN-beta production. IFN-beta is used clinically for treatment of tumors, infections, and multiple sclerosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.