Thermo Fisher Scientific IFN beta Monoclonal Antibody (A1 (IFNb)), Biotin, eBioscience
인간 IFN-beta를 인식하는 단클론 항체로, 자연형 및 재조합형 IFN-beta1a/b를 중화 가능. ELISA, Western blot, 기능적 분석에 적합. Biotin 결합 형태로 제공되며, 2–8°C에서 보관. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| ELISA | Assay-dependent |
| Functional Assay | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | A1 (IFNb) |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | TBS, pH 7.2–7.4, with 1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | 2–8°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11217474 |
Available Formats
Product Specific Information
The IFNb/A1 clone recognizes natural human IFN-beta and recombinant IFN-beta1a and IFN-beta1b. It is capable of neutralizing IFN-beta.
Interferon beta is synthesized and secreted by fibroblasts and many other cell types in response to pathogens. IFN-beta binding to type I interferon receptors induces the upregulation of IRF-7 and activation of RNase L. IRF-7 can exert a positive feedback on IFN-beta production. RNase L cleaves both viral and cellular single-stranded mRNA, thereby limiting viral replication and dissemination.
Applications Tested: ELISA, Neutralization tests, Western Blotting.
Target Information
Type I Interferons (IFN-alpha/beta) are produced primarily in response to viral infection by Natural IFN-producing cells (IPCs) as part of the host immune response. IFNs can also inhibit the development of tumors. IFN-beta binding results in activation of the tyrosine kinases Jak1 and Tyk2, phosphorylation of STAT family transcription factors, and transcription of immune response genes. Several members of the Toll-like receptor (TLR) family also stimulate IFN-beta production. IFN-beta is used clinically for treatment of tumors, infections, and multiple sclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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