Thermo Fisher Scientific Galectin 3 Monoclonal Antibody (eBioM3/38 (M3/38)), eBioscience

Applications and Tested Dilutions

Product Specifications

Additional Formats

• Biotin
• eFluor 660
• PE
• Request custom conjugation

Product Specific Information

The Anti-human Galectin-3 (M3/38) antibody recognizes an epitope in the N-terminal half of lectin. Galectins are a family of animal lectins with various biological functions. Galectin-3 (LGALS3, Mac-2, L-29) is a 30 kDa beta-galactoside-binding protein that binds IgE and mammalian cell surfaces when homodimerized or homo-oligomerized. It is distributed in epithelial tissues and inflammatory cells such as macrophages, dendritic cells, and Kupffer cells. Expression is upregulated during inflammation, proliferation, differentiation, and viral trans-activation.

Applications Tested: ELISA, Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Western Blotting.

Target Information

Galectin-3 is a galactose-specific lectin that binds IgE and may mediate endothelial cell migration via alpha-3, beta-1 integrin interaction. Together with DMBT1, it is required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus, it functions as a pre-mRNA splicing factor and plays roles in acute inflammatory responses including neutrophil activation, monocyte chemoattraction, macrophage activation, opsonization of apoptotic neutrophils, and mast cell activation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.