Thermo Fisher Scientific Phospho-Tyrosine Hydroxylase (Ser40) Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Antibody detects endogenous levels of Tyrosine Hydroxylase only when phosphorylated at Serine 40.

Target Information

Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters such as dopamine, epinephrine, and norepinephrine. Catecholamine synthesis is regulated by the interaction of TH with the cofactor tetrahydrobiopterin (BH4), which binds to the TH catalytic domain to enable enzymatic activity.

In humans, four TH mRNA splice variants (hTH1–hTH4) have been identified. These variants share identical catalytic domains but differ in their N-terminal regulatory domains. TH catalyzes the conversion of L-tyrosine to L-dopa and plays a crucial role in adrenergic neuron physiology.

The enzyme’s function in catecholamine synthesis implicates it in several neuropathogenic diseases, including Parkinson’s disease, schizophrenia, Segawa syndrome, dystonia, and various cardiovascular conditions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.