Thermo Fisher Scientific Phospho-HDAC1 (Ser421) Polyclonal Antibody
HDAC1의 Ser421 인산화 형태를 인식하는 Rabbit Polyclonal 항체. Western blot과 Immunocytochemistry에 사용 가능. 인간, 마우스, 랫트 반응성. 1 mg/mL 액상 형태로 PBS/glycerol buffer에 보관. -20°C에서 보관, 연구용 전용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human HDAC1 (Accession Q13547), corresponding to amino acid residues around phosphorylated Ser421 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816462 |
Product Specific Information
This antibody detects endogenous levels of HDAC1 only when phosphorylated at Serine 421.
Target Information
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. HDAC1 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It interacts with the retinoblastoma tumor-suppressor protein, forming a complex that regulates cell proliferation and differentiation. Together with metastasis-associated protein-2, HDAC1 deacetylates p53 and modulates its effect on cell growth and apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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