Thermo Fisher Scientific Phospho-SMC1 (Ser957) Polyclonal Antibody
Phospho-SMC1 (Ser957) 특이적 폴리클로날 항체로, 인산화된 SMC1 단백질 검출에 적합합니다. Western blot, IHC, ICC/IF에 사용 가능하며, Human, Mouse, Rat 반응성을 가집니다. 고순도 정제 및 안정적 액상 형태로 -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SMC1A (Accession Q14683), corresponding to amino acid residues around phosphorylated Ser957 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816465 |
Product Specific Information
This antibody detects endogenous levels of SMC1 only when phosphorylated at Serine 957.
Target Information
Structural Maintenance of Chromosomes (SMC) family proteins are essential for nuclear events involving chromosomal structural changes, including mitotic chromosome organization, DNA recombination and repair, and transcriptional repression.
SMC1 and SMC3 form a heterodimeric complex required for metaphase progression and sister chromatid cohesion.
Mutations in the SMC1 gene are associated with Cornelia de Lange syndrome 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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