Thermo Fisher Scientific PPOX Polyclonal Antibody
Thermo Fisher Scientific의 PPOX Polyclonal Antibody는 인간 및 생쥐 시료에서 PPOX 단백질 검출에 적합한 토끼 폴리클로날 항체입니다. Western blot, IHC, ELISA 등 다양한 응용에 사용 가능하며, 고순도 친화 크로마토그래피 정제 및 안정한 PBS/glycerol 보존액 형태로 제공됩니다.
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- PA5117044
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- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–280 of human PPOX (NP_001116236.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.47 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2901674 |
Product Specific Information
- Positive Samples: HepG2, Mouse spleen, Mouse liver, Mouse kidney
- Immunogen sequence:
MGRTVVVLGG GISGLAASYH LSRAPCPPKV VLVESSERLG GWIRSVRGPN GAIFELGPRG IRPAGALGAR TLLLVSELGL DSEVLPVRGD HPAAQNRFLY VGGALHALPT GLRGLLRPSP PFSKPLFWAG LRELTKPRGK EPDETVHSFA QRRLGPEVAS LAMDSLCRGV FAGNSRELSI RSCFPSLFQA EQTHRSILLG LLLGAGRTPQ PDSALIRQAL AERWSQWSLR GGLEMLPQAL ETHLTSRGVS VLRGQPVCGL SLQAEGRWKV SLRDSSLEAD
Target Information
Protoporphyrinogen oxidase (PPOX) is the penultimate enzyme in the heme biosynthetic pathway, catalyzing the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX. PPOX is localized to the inner mitochondrial membrane in tissues such as heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas.
Genetic deficiency of PPOX results in variegate porphyria (VP), an autosomal dominant disorder characterized by cutaneous photosensitivity and neurological manifestations. The rare homozygous variant of VP leads to severe PPOX deficiency, early-onset photosensitization, skeletal abnormalities, short stature, mental retardation, and convulsions.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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