Thermo Fisher Scientific PPOX Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Positive Samples: HepG2, Mouse spleen, Mouse liver, Mouse kidney
• Immunogen sequence:
  MGRTVVVLGG GISGLAASYH LSRAPCPPKV VLVESSERLG GWIRSVRGPN GAIFELGPRG IRPAGALGAR TLLLVSELGL DSEVLPVRGD HPAAQNRFLY VGGALHALPT GLRGLLRPSP PFSKPLFWAG LRELTKPRGK EPDETVHSFA QRRLGPEVAS LAMDSLCRGV FAGNSRELSI RSCFPSLFQA EQTHRSILLG LLLGAGRTPQ PDSALIRQAL AERWSQWSLR GGLEMLPQAL ETHLTSRGVS VLRGQPVCGL SLQAEGRWKV SLRDSSLEAD

Target Information

Protoporphyrinogen oxidase (PPOX) is the penultimate enzyme in the heme biosynthetic pathway, catalyzing the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX. PPOX is localized to the inner mitochondrial membrane in tissues such as heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas.
Genetic deficiency of PPOX results in variegate porphyria (VP), an autosomal dominant disorder characterized by cutaneous photosensitivity and neurological manifestations. The rare homozygous variant of VP leads to severe PPOX deficiency, early-onset photosensitization, skeletal abnormalities, short stature, mental retardation, and convulsions.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.