Thermo Fisher Scientific SH2D1A Polyclonal Antibody
SH2D1A 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 폴리클로날 항체. Western blot 및 면역침전(IP)에 사용 가능하며, 인간 시료에 반응. 합성 펩타이드 항원을 기반으로 제작되어 높은 특이성과 재현성을 제공.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.2–0.6 µg/mL |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (QYPVEKKSSARSTQ) corresponding to the internal amino acids of SH2D1A (aa 99–113). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10978047 |
Product Specific Information
- This antibody is predicted to react with porcine based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 32,000.
Target Information
This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. It contains an SH2 domain and a short tail and associates with the signaling lymphocyte-activation molecule (SLAM), acting as an inhibitor by blocking the recruitment of SHP-2 to its docking site. It can also bind to other related surface molecules expressed on activated T, B, and NK cells, modifying signal transduction pathways. Mutations in this gene cause X-linked lymphoproliferative syndrome type 1 (Duncan disease), a rare immunodeficiency associated with susceptibility to Epstein-Barr virus infection, severe mononucleosis, and malignant lymphoma. Multiple transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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