Thermo Fisher Scientific Klotho Polyclonal Antibody
인간 Klotho 단백질을 인식하는 염소 유래 폴리클로날 항체입니다. IHC(P)에서 4–6 µg/mL로 사용 권장되며, 마우스와 랫트에서도 반응이 예측됩니다. 항체는 액상 형태로 제공되며, 0.5 mg/mL 농도와 TBS(pH 7.3), 0.5% BSA, 0.02% sodium azide를 포함합니다. -20°C에서 보관하십시오.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 4–6 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (KRDDAKYMYYLKK) corresponding to internal amino acids of KL (aa 424–437) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_10983137 |
Product Specific Information
- Predicted to react with mouse and rat based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 1:4,000.
- Preliminary analysis showed no signal in Western Blot.
Target Information
KLOTHO is a systemic anti-aging hormone within the glycosidase 1 superfamily. It encodes a type I membrane protein abundant in the kidney and brain.
In mice, KLOTHO deficiency leads to phenotypes resembling human aging, such as arteriosclerosis, osteoporosis, and skin atrophy, along with growth retardation, shortened lifespan, and infertility.
Overexpression of KLOTHO extends lifespan by inhibiting insulin/IGF1 signaling.
It also regulates calcium/phosphorus homeostasis by inhibiting active vitamin D synthesis and is identified as a potential tumor suppressor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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