ELK Biotechnology CEP170 rabbit pAb
Human CEP170 단백질을 인식하는 rabbit polyclonal antibody로, WB, IHC, IF, ELISA에 적합합니다. 세포골격 및 중심체 관련 연구에 활용되며, 고순도(1 mg/ml) IgG 형태로 제공됩니다. -20°C에서 1년간 안정적으로 보관 가능합니다.
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ELK Biotechnology CEP170 rabbit pAb
제품 개요
CEP170 단백질에 특이적인 rabbit polyclonal antibody로, 세포골격 및 중심체 관련 연구에 적합합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | CEP170 rabbit pAb |
| Alternative Names | CEP170; FAM68A; KAB; KIAA0470; Centrosomal protein of 170 kDa; Cep170; KARP-1-binding protein; KARP1-binding protein |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 ELISA: 1/40000 Other applications: Not yet tested |
| Immunogen | Synthesized peptide derived from human CEP170 (AA range: 701–750) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 160 kDa |
| GeneID (Human) | 9859 |
| Human Swiss-Prot No | Q5SW79 |
| Species Reactivity | Human; Rat; Mouse |
| Cellular Localization | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole, spindle. Associated with the mature mother centriole and spindle microtubules during mitosis. Localizes to distal appendage region and centriole proximal ends (PubMed:31789463). |
Background
Centrosomal protein 170 (CEP170) is a component of the centrosome, a non-membraneous organelle functioning as the major microtubule-organizing center in animal cells. During interphase, CEP170 localizes to the sub-distal appendages of mature centrioles, helping organize centrosomes. During mitosis, it associates with spindle microtubules near centrosomes. The protein interacts with and is phosphorylated by polo-like kinase 1, maintaining microtubule organization and cell morphology. The human genome contains a putative transcribed pseudogene, and several alternatively spliced transcript variants exist.
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