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ELK Biotechnology Cdk1/Cdc2 rabbit pAb
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Cyclin-dependent kinase 1(CDK1/Cdc2)을 인식하는 rabbit polyclonal antibody로, WB, IHC, IF, ELISA에 사용 가능. 세포주기 조절 연구에 적합하며, 인간, 마우스, 랫트에 반응. 합성 펩타이드 면역원으로 제작, -20°C에서 1년 보관 가능.
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- pk
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ELK Biotechnology ES1938-100UL Cdk1/Cdc2 rabbit pAb, 100UL pk판매 단위 pk ·
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402,000원VAT 포함 442,200원
ELK Biotechnology ES1938-50UL Cdk1/Cdc2 rabbit pAb, 50UL pk판매 단위 pk ·
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301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology Cdk1/Cdc2 rabbit pAb
제품명
Cdk1/Cdc2 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | CDK1; CDC2; CDC28A; CDKN1; P34CDC2; Cyclin-dependent kinase 1; Cell division control protein 2 homolog; Cell division protein kinase 1; p34 protein kinase |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human CDC2 (AA range: 101–150) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 34 kD |
| Gene ID (Human) | 983 |
| Human Swiss-Prot No. | P06493 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Nucleus, Cytoplasm, Mitochondrion, Cytoskeleton (microtubule organizing center, centrosome, spindle). Cytoplasmic during interphase. Colocalizes with SIRT2 on centrosome during prophase and spindle fibers during metaphase. Reversibly translocated from cytoplasm to nucleus when phosphorylated before G2-M transition with cyclin-B1. Accumulates in mitochondria in G2-arrested cells upon DNA-damage. |
Background
Cyclin-dependent kinase 1 (CDK1) is a member of the Ser/Thr protein kinase family and a catalytic subunit of the M-phase promoting factor (MPF), essential for G1/S and G2/M transitions in the eukaryotic cell cycle. Mitotic cyclins associate with CDK1 as regulatory subunits. The kinase activity is regulated by cyclin accumulation and degradation, as well as phosphorylation and dephosphorylation events. Alternatively spliced transcript variants encoding different isoforms have been identified.
[Provided by RefSeq, Mar 2009]
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