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ELK Biotechnology Cdk1/2/3 rabbit pAb
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CDK1/2/3 단백질을 인식하는 토끼 폴리클로날 항체로, Western blot 및 ELISA에 적합합니다. 세포주기 조절 연구에 활용되며, 고순도 IgG 형태로 제공됩니다. -20°C에서 1년간 안정적으로 보관 가능합니다.
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ELK Biotechnology ES1937-100UL Cdk1/2/3 rabbit pAb, 100UL pk판매 단위 pk ·
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402,000원VAT 포함 442,200원
ELK Biotechnology ES1937-50UL Cdk1/2/3 rabbit pAb, 50UL pk판매 단위 pk ·
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301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology Cdk1/2/3 rabbit pAb
제품명
Cdk1/2/3 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | CDK1; CDC2; CDC28A; CDKN1; P34CDC2; Cyclin-dependent kinase 1; Cell division control protein 2 homolog; Cell division protein kinase 1; p34 protein kinase; CDK2; CDKN2; Cyclin-dependent kinase 2; Cell division protein kinase 2; p33 protein kinase |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human CDK1/CDC2 (AA range: 1-50) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 34 kDa |
| Gene ID (Human) | 1017 |
| Human Swiss-Prot No. | P06493 / P24941 / Q00526 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Nucleus; Cytoplasm; Mitochondrion; Cytoskeleton (microtubule organizing center, centrosome, spindle). Cytoplasmic during interphase. Colocalizes with SIRT2 on centrosome during prophase and on spindle fibers during metaphase. Reversibly translocated from cytoplasm to nucleus before G2-M transition when associated with cyclin-B1. Accumulates in mitochondria in G2-arrested cells upon DNA damage. |
Background
Cyclin dependent kinase 1 (CDK1) is a member of the Ser/Thr protein kinase family and functions as a catalytic subunit of the M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions in the eukaryotic cell cycle. Mitotic cyclins associate with CDK1 as regulatory subunits, and its kinase activity is regulated by cyclin accumulation and degradation. Phosphorylation and dephosphorylation of CDK1 play crucial roles in cell cycle control. Alternative splicing results in multiple isoforms of this protein.
(Information provided by RefSeq, Mar 2009)
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