ELK Biotechnology CD4 rabbit pAb
CD4 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간 및 생쥐 시료에 반응하며, 세포막 단백질 분석에 적합. HIV 연구 및 면역 관련 질환 연구에 활용 가능.
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제품명
CD4 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | CD4 rabbit pAb |
| Alternative Names | CD4; T-cell surface glycoprotein CD4; T-cell surface antigen T4/Leu-3; CD antigen CD4 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 IHC-p: 1/100–1/300 ELISA: 1/20000 IF: 1/100–1/300 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CD4 (AA range: 401–450) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 51 kD |
| Gene ID (Human) | 920 |
| Human Swiss-Prot No | P01730 |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein. Localizes to lipid rafts (PubMed:12517957, PubMed:9168119). Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with and sequesters CD4 in the endoplasmic reticulum. |
| Species Reactivity | Human; Mouse |
Background
This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigens and also serves as a receptor for the human immunodeficiency virus (HIV). The gene is expressed not only in T lymphocytes but also in B cells, macrophages, and granulocytes, as well as in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation and may act as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene (RefSeq, Aug 2010).
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