ELK Biotechnology Actinin-α2/3 rabbit pAb
Actinin-α2/3 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 사람, 생쥐, 랫트 반응성. 근육 및 세포골격 연구에 적합하며, -20°C에서 1년 보관 가능.
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Actinin-α2/3 rabbit pAb
제품 개요
Actinin-α2/3 단백질을 인식하는 토끼 폴리클로날 항체로, 세포골격 및 근육 단백질 연구에 활용됩니다. 다양한 응용 분야(WB, IHC, IF, ELISA)에 적합하며, 인체 및 동물 모델에서의 발현 분석에 유용합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Actinin-α2/3 rabbit pAb |
| Alternative Names | ACTN2; Alpha-actinin-2; Alpha-actinin skeletal muscle isoform 2; F-actin cross-linking protein; ACTN3; Alpha-actinin-3; Alpha-actinin skeletal muscle isoform 3; F-actin cross-linking protein |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 Immunofluorescence: 1/200–1/1000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Actinin alpha-2/3 (AA range: 31–80) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 103 kD |
| Gene ID (Human) | 88 / 89 |
| Human Swiss-Prot No. | P35609 / Q08043 |
| Cellular Localization | Cytoplasm, myofibril, sarcomere, Z line. Colocalizes with MYOZ1 and FLNC at the Z-lines of skeletal muscle. |
| Species Reactivity | Human; Mouse; Rat |
Background
Alpha actinins belong to the spectrin gene superfamily, which includes alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, it is found along microfilament bundles and adherens-type junctions, binding actin to the membrane. In muscle cells (skeletal, cardiac, smooth), it localizes to the Z-disc or analogous dense bodies, anchoring myofibrillar actin filaments. This gene encodes a muscle-specific alpha actinin isoform expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been identified (RefSeq, May 2013).
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