ELK Biotechnology Akt rabbit pAb
AKT 단백질을 인식하는 rabbit polyclonal antibody로, IF, WB, IHC, ELISA에 사용 가능. Human, Mouse, Rat, Chicken에 반응. 세포 내 Akt 활성화 및 위치 연구에 적합. 고순도 IgG, -20°C에서 1년 보관 가능.
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Akt rabbit pAb
제품 개요
ELK Biotechnology의 Akt rabbit polyclonal antibody는 인간 AKT1/2/3 유래 합성 펩타이드를 면역원으로 제작된 항체로, 세포 내 Akt 단백질의 발현 및 활성화를 탐지하는 데 사용됩니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Akt rabbit pAb |
| Alternative Names | AKT1; PKB; RAC; RAC-alpha serine/threonine-protein kinase; Protein kinase B; PKB alpha; Proto-oncogene c-Akt; RAC-PK-alpha; AKT2; RAC-beta serine/threonine-protein kinase; Protein kinase Akt-2; Protein kinase B |
| Applications | IF; WB; IHC; ELISA |
| Recommended Dilutions | IF: 1:50–200 WB: 1:500–1:2000 IHC: 1:100–1:300 ELISA: 1:40000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human AKT1/2/3 (AA range: 281–330) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 56 kD |
| Gene ID (Human) | 207 / 208 / 10000 |
| Human Swiss-Prot No. | P31749 / P31751 / Q9Y243 |
| Species Reactivity | Human; Mouse; Rat; Chicken |
| Cellular Localization | Cytoplasm, Nucleus, Cell membrane. Translocates to the nucleus after activation by ILK1. Localization to the cell membrane occurs upon phosphorylation by TNK2, followed by further phosphorylation at Thr-308 and Ser-473, leading to activation. Colocalizes with WDFY2 in intracellular vesicles (PubMed:16792529). |
Background
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved fibroblasts but becomes activated by platelet-derived growth factor. Activation occurs through phosphatidylinositol 3-kinase and is essential for growth factor-induced neuronal survival. AKT1 phosphorylates and inactivates apoptotic machinery components, suppressing apoptosis. Mutations in AKT1 are associated with Proteus syndrome. Multiple alternatively spliced transcript variants have been identified (RefSeq, Jul 2011).
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