ELK Biotechnology Caspase-10 B/D rabbit pAb
Caspase-10 단백질을 인식하는 토끼 폴리클로날 항체로, apoptosis 관련 연구에 적합합니다. WB, IHC, IF, ELISA 등 다양한 응용에 사용 가능하며, 인간, 생쥐, 랫트에 반응합니다. -20°C에서 1년 보관 가능합니다.
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Caspase-10 B/D Rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product Name | Caspase-10 B/D rabbit pAb |
| Alternative Names | ALPS2; apoptotic protease Mch-4; CASP-10; CASPA; caspase-10; FADD-like ICE2; FAS-associated death domain protein interleukin-1B-convert |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Caspase-10 (AA range: 430–479) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | pro: 60 kDa, activated: 33 kDa, 12 kDa |
| Gene ID (Human) | 843 |
| Human Swiss-Prot No. | Q92851-2/4 |
| Cellular Localization | Cytosol, CD95 death-inducing signaling complex, Ripoptosome |
| Species Reactivity | Human; Rat; Mouse |
Background
This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce large and small subunits, which dimerize to form the active enzyme. Caspase-10 cleaves and activates caspases 3 and 7, and is itself processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma, and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. (RefSeq, Apr 2011)
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