ELK Biotechnology BRCA1 rabbit pAb
BRCA1 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간 BRCA1 유래 합성 펩타이드로 면역화됨. 핵 및 세포질에 위치하며 DNA 손상 복구 연구에 적합. -20°C에서 1년 보관 가능.
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제품명
BRCA1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | BRCA1; RNF53; Breast cancer type 1 susceptibility protein; RING finger protein 53 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human BRCA1 (AA range: 1391–1440) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 672 |
| Human Swiss-Prot No. | P38398 |
| Species Reactivity | Human; Rat |
| Cellular Localization | Nucleus, Chromosome, Cytoplasm. Localizes at sites of DNA damage at double-strand breaks (DSBs); recruitment to DNA damage sites is mediated by ABRAXAS1 and the BRCA1-A complex (PubMed:26778126). Translocated to the cytoplasm during UV-induced apoptosis (PubMed:20160719). Isoform 3: Cytoplasm; Isoform 5: Cytoplasm. |
Background
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). It associates with RNA polymerase II and interacts with histone deacetylase complexes through the C-terminal domain. This protein plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing modulates subcellular localization and physiological function, producing multiple transcript variants.
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