Thermo Fisher Scientific PGR Monoclonal Antibody (OTI14G1), TrueMAB
Progesterone receptor(PGR)을 인식하는 마우스 단클론 항체로, Western blot에 최적화됨. 인간 단백질(aa 1-298)을 항원으로 제작. 액상 형태, 1 mg/mL 농도, PBS/BSA/glycerol 버퍼에 보관. 연구용으로만 사용 가능.
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- TA802560
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Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI14G1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–298 of human PGR produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20 °C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. It mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with pregnancy.
PR exists as a 94 kDa protein (Form A) or a 120 kDa protein (Form B) due to alternative translation initiation sites. PR‑B is transcriptionally active and regulates genes for endometrial maintenance, pregnancy, and inhibition of ovulation.
PR‑A is identical to PR‑B except for a 165‑amino‑acid deletion at the N‑terminus, exposing a 140‑amino‑acid inhibitory domain that represses steroid hormone transcriptional activity.
In its inactive state, PgR forms a multiprotein complex with heat shock proteins and immunophilins. Upon progesterone binding, conformational changes enable dimerization and binding to progesterone response elements (PRE), activating transcription.
A null mutation in the PGR gene leads to pleiotropic reproductive abnormalities.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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