Thermo Fisher Scientific APOBEC3G Polyclonal Antibody
Human APOBEC3G 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에 최적화되어 있습니다. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol 완충액에 보관됩니다. 연구용으로 HIV 관련 연구 및 세포 내 항바이러스 메커니즘 분석에 활용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human APOBEC3G |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.94 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol, 1% BSA |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792474 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Chimpanzee (96%).
- Positive Control: A431, Jurkat, Raji.
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
The Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (APOBEC) 3 family includes multiple isoforms of cytidine deaminases acting on monomeric nucleosides and nucleotides.
APOBEC3 plays a major role in cellular defense against retroviral infection. Isoforms APOBEC3G and APOBEC3F can be incorporated into HIV-1 virions, inducing hypermutation in viral DNA and destabilizing the viral genome.
HIV-1 Vif protein counteracts this defense by inducing ubiquitination and degradation of APOBEC3G. A single amino acid substitution (D128K) can block APOBEC3G depletion without affecting its antiviral activity.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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