Thermo Fisher Scientific Phospho-Dynamin 1 (Ser774) Polyclonal Antibody
Phospho-Dynamin 1 (Ser774) 인산화 부위를 인식하는 Rabbit Polyclonal 항체로, WB 및 IHC(P)에서 사용 가능. 인간, 마우스, 랫트 반응성. 1 mg/mL 액상 형태로 PBS/glycerol buffer에 보관. 연구용 전용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human DNM1 (Accession Q05193), corresponding to amino acid residues around phosphorylated Ser774 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816436 |
Product Specific Information
This antibody detects endogenous levels of Dynamin 1 only when phosphorylated at Serine 774.
Target Information
Dynamin is a GTPase required for endocytosis of clathrin-coated vesicles from the membrane. Its role in endocytosis was first identified through studies of the temperature-sensitive shibire mutation in Drosophila melanogaster.
In mammals, three closely related isoforms exist:
- Dynamin 1: Expressed exclusively in neurons
- Dynamin 2: Ubiquitously expressed
- Dynamin 3: Expressed primarily in the testes
Each isoform has multiple splice variants that may function in distinct vesicle budding processes. Dynamin proteins share common domains: an N-terminal GTPase domain, a central pleckstrin homology domain, and a proline-rich C-terminal region containing SH3 domains that target the protein to clathrin-coated pits. Dynamin interacts with proteins such as the AP2 adaptor complex and amphiphysin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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