Thermo Fisher Scientific SARS-CoV-2 Spike Protein S1 Monoclonal Antibody (HL1)
SARS-CoV-2 스파이크 단백질 S1을 특이적으로 인식하는 Rabbit IgG 단클론 항체. Western blot, ICC/IF, ELISA 등에 사용 가능. SARS-CoV 및 MERS-CoV 스파이크 단백질과 교차 반응 없음. 연구용으로만 사용.
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Applications
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:10,000 | |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | |
| ELISA | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | HL1 |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminal region of SARS-CoV-2 (COVID-19) spike. The exact sequence is proprietary. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.08 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2890585 |
Product Specific Information
- Specificity: This antibody detects SARS-CoV-2 Spike protein, but does not cross-react with SARS-CoV or MERS-CoV spike proteins based on internal testing.
Target Information
SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2), also known as 2019-nCoV (2019 Novel Coronavirus), is a virus that causes illnesses ranging from mild cold-like symptoms to severe respiratory distress and death.
The SARS-CoV-2 Spike Protein consists of S1 and S2 domains and serves as the main surface antigen of the coronavirus.
The glycosylated Spike protein, along with the nucleocapsid protein, can be detected in infected cell culture supernatants using antisera from SARS patients.
The S1 domain contains the receptor-binding domain (RBD), which specifically binds to the angiotensin-converting enzyme 2 (ACE2) receptor on target cells.
Variations in Spike proteins among coronaviruses reflect their diversity, influencing receptor interactions and responses to environmental triggers of virus-cell membrane fusion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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