Thermo Fisher Scientific Menin Recombinant Rabbit Monoclonal Antibody (8G11)

Thermo Fisher Scientific Menin Recombinant Rabbit Monoclonal Antibody (8G11)

Applications

• Western Blot (WB)

Tested Dilution

• 1:500–1:5,000

Publications

• [References not provided]

Product Specifications

Product Specific Information

This antibody has been tested in direct ELISA.

Target Information

Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10-fold the concentration of calcium required to keep the pore open.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

• MA5-38326_Menin_O00255-1_Rabbit.svg
• MA5-38326_Menin_O00255-1_Rabbit_PDP.jpeg