Thermo Fisher Scientific PAX2 Polyclonal Antibody, Biotin
PAX2 단백질을 인식하는 Biotin 결합 토끼 다클론 항체로, Western blot, ELISA, IP에 적합합니다. 사람, 생쥐, 랫트 시료에 반응하며, Affinity chromatography로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 310–360 on human PAX2 protein |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The PAX gene family encodes transcription factors active in specific tissues during early embryonic development. These genes contain a paired box domain that enables DNA binding and gene regulation. Mutations in PAX genes are linked to developmental disorders such as Waardenburg syndrome (PAX3), Aniridia (PAX6), and Wilms tumor (PAX2).
During embryogenesis, PAX2 is expressed in the developing kidney, particularly in condensing metanephric mesenchyme and early epithelial structures. PAX2 expression decreases as the renal epithelium matures but persists in undifferentiated epithelial cells of Wilms tumors. The Wilms tumor suppressor protein WT1 is known to downregulate PAX2 transcription, suggesting a regulatory relationship between WT1 and PAX2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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