Thermo Fisher Scientific KCNK18 Polyclonal Antibody
Rabbit polyclonal antibody against human KCNK18 (TRESK). Validated for WB and IHC. Lyophilized form, reconstitutable in sterile water. Suitable for research use in studies of potassium channel regulation and T-cell function.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | – |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | – |
| Miscellaneous PubMed (Misc) | – | View 2 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from amino acid region 10–100 of human KCNK18 (TRESK, KCNKI) conjugated to an immunogenic carrier protein. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4 °C short term. For long-term storage, store at −20 °C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity: KCNK18.
Target Information
TRESK (TWIK-related spinal cord K⁺ channel) is a two-pore domain potassium channel that induces outward rectification and functions as a background K⁺ channel. It is abundantly expressed in the spinal cord, thymus, spleen, and leukemic T-lymphocytes.
TRESK is activated by increased cytoplasmic calcium concentration through calcineurin, as well as by acetylcholine and histamine. It has been suggested that TRESK is linked to acute and chronic pain via calcineurin activation. Other studies indicate that TRESK may regulate T-cell function and could be a potential target in treating T-cell–originated immune dysfunction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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