Thermo Fisher Scientific Calprotectin Monoclonal Antibody (MAC387), PE
인간 Calprotectin 단백질을 인식하는 MAC387 클론 단일클론 항체로, PE 형광체가 결합된 제품입니다. Flow Cytometry에 적합하며 단핵세포 및 대식세포 표지에 활용됩니다. 단백질 A로 정제되었으며, PBS + 1% BSA 용액에 보관됩니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific Calprotectin Monoclonal Antibody (MAC387), PE
Applications
- Flow Cytometry (Flow)
Tested Dilution: Neat - 1/5
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MAC387 |
| Immunogen | Human monocytes |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Lyophilized |
| Concentration | Not Determined |
| Purification | Protein A |
| Storage Buffer | PBS with 1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745113 |
Additional Formats
- Unconjugated ([MA1-81381])
- APC ([MA5-28129])
- FITC ([MA1-80263])
- Request custom conjugation available
Product Specific Information
Reconstitute with 1.0 mL of distilled water.
Mouse anti-Human macrophages, clone MAC387 recognizes the L1 or Calprotectin molecule, an intracytoplasmic antigen comprised of a 12 kDa alpha chain and a 14 kDa beta chain.
Target Information
The S100A8/A9 heterocomplex, also known as MRP-8/MRP-14 complex or calprotectin, constitutes about 60% of the cytoplasmic protein fraction of circulating polymorphonuclear granulocytes and is also found in monocytes, macrophages, and ileal tissue eosinophils.
Peripheral blood monocytes carry the antigen extra- and intracellularly, while neutrophils contain it only intracellularly. The S100A8/A9 complex exhibits antibacterial, antifungal, immunomodulating, and antiproliferative properties, and acts as a potent chemotactic factor for neutrophils.
Elevated plasma concentrations are associated with diseases involving increased neutrophil activity, such as inflammatory bowel disease. Calprotectin is detectable in feces and other body fluids (plasma, saliva, gingival crevicular fluid, stools, synovial fluid) during infection and inflammatory conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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