Thermo Fisher Scientific Calprotectin Monoclonal Antibody (MAC387), APC
인간 Calprotectin(L1) 인식하는 MAC387 클론 단일클론 항체로 APC 형광표지. Flow Cytometry 등 연구용에 적합. 단백질 A 정제, PBS/BSA/sucrose 완충액, 4°C 보관. 염증성 질환 연구 및 면역세포 분석에 활용.
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Thermo Fisher Scientific Calprotectin Monoclonal Antibody (MAC387), APC
Applications
- Flow Cytometry (Flow)
Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MAC387 |
| Immunogen | Human monocytes (Calprotectin, UniProt ID: P06702-1, P05109-1) |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Lyophilized |
| Concentration | Not determined |
| Purification | Protein A |
| Storage Buffer | PBS with 1% BSA, 5% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745112 |
Additional Formats
- Unconjugated
- FITC
- PE
- Custom conjugation available upon request
Product Specific Information
Reconstitute with 1.0 mL distilled water.
Mouse anti-human macrophages, clone MAC387, recognizes the L1 or Calprotectin molecule—an intracytoplasmic antigen comprised of a 12 kDa alpha chain and a 14 kDa beta chain.
Target Information
The S100A8/A9 heterocomplex (MRP-8/MRP-14 complex or calprotectin) constitutes ~60% of the cytoplasmic protein fraction of circulating polymorphonuclear granulocytes and is also found in monocytes, macrophages, and ileal tissue eosinophils.
Peripheral blood monocytes carry the antigen extra- and intracellularly, while neutrophils only intracellularly.
This complex exhibits antibacterial, antifungal, immunomodulating, and antiproliferative effects, and acts as a potent chemotactic factor for neutrophils.
Plasma concentrations are elevated in diseases associated with increased neutrophil activity (e.g., inflammatory bowel disease).
Calprotectin is detectable in feces and other body fluids (plasma, saliva, gingival crevicular fluid, stools, synovial fluid) during infection and inflammation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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