Thermo Fisher Scientific CD134 (OX40) Monoclonal Antibody (ACT35 (ACT-35)), APC, eBioscience

Thermo Fisher Scientific CD134 (OX40) Monoclonal Antibody (ACT35 (ACT-35)), APC, eBioscience™

Applications

• Flow Cytometry (Flow)

Tested Dilution: 5 µL (0.125 µg)/test
Publications: View 2 publications

Product Specifications

Additional Formats

• Unconjugated
• FITC
• PE
• PE-Cyanine7
• Request custom conjugation

Product Specific Information

The ACT35 monoclonal antibody reacts with human CD134, also known as OX-40. A member of the TNF receptor superfamily, CD134/OX-40 is a 50 kDa type I membrane glycoprotein expressed by activated T lymphocytes.
The interaction of CD134 with OX-40L has been implicated in:

• T cell-dependent humoral response
• Regulation of primary T cell expansion and survival
• Maintenance of memory T cell pool
• Regulation of tolerance in CD4⁺ T cell compartment

Applications Reported: Flow cytometric analysis
Applications Tested: Pre-titrated for 3-day PHA-stimulated normal human peripheral blood cells
Recommended use: 5 µL (0.125 µg) per test in a final volume of 100 µL
Cell number range: 10⁵–10⁸ cells/test

Excitation: 633–647 nm
Emission: 660 nm
Laser: Red Laser
Filtration: 0.2 µm post-manufacturing filtered

Target Information

OX40 is a protein receptor found on the surface of T cells, playing a critical role in immune activation. When engaged, OX40 promotes T cell proliferation and survival, enhancing immune responses against cancer and infections.
OX40 agonists are under investigation as potential immunotherapies, showing synergy with chemotherapy and checkpoint inhibitors, and possible applications in autoimmune and allergic diseases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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