Thermo Fisher Scientific CD134 (OX40) Monoclonal Antibody (OX40), APC, eBioscience
Thermo Fisher Scientific의 CD134 (OX40) Monoclonal Antibody는 rat CD134에 특이적으로 반응하는 APC 결합 항체로, 활성화된 T 세포 분석에 적합합니다. Flow Cytometry용으로 검증되었으며, 0.125 µg/test로 최적화 가능합니다. 4°C에서 암소 보관하며 동결 금지.
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Applications and Tested Dilution
- Application: Flow Cytometry (Flow)
- Tested Dilution: 0.125 µg/test
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat |
| Host / Isotype | Mouse / IgG2b, kappa |
| Recommended Isotype Control | Mouse IgG2b kappa Isotype Control (eBMG2b), APC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OX40 |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2573160 |
Product Specific Information
The monoclonal antibody OX40 reacts with rat CD134, a 50-kDa glycoprotein belonging to the TNFR superfamily. CD134 (OX40) is expressed on activated T cells, including TH1, TH2, TH17, and Tregs, but not on naive CD4/CD8 T cells or most memory cells. It is inducible on NKT cells, neutrophils, and NK cells.
CD134 binds to CD252 (OX40L) to mediate T cell expansion, survival, and memory generation, and plays a role in Treg suppression and immune tolerance.
- Applications Reported: Flow cytometric analysis
- Applications Tested: Flow cytometric analysis of stimulated rat splenocytes (≤ 0.125 µg/test)
- Recommended Use: Titrate for optimal assay performance
- Excitation: 633–647 nm
- Emission: 660 nm
- Laser: Red Laser
- Filtration: 0.2 µm post-manufacturing filtered
Target Information
OX40 is a receptor on T cells that promotes proliferation and survival upon activation, enhancing immune responses against cancer and infections. OX40 agonists show promise in immunotherapy, improving outcomes in cancer treatment and potentially in autoimmune and allergic diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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