Thermo Fisher Scientific CD31 Recombinant Rabbit Monoclonal Antibody (078)

Applications and Tested Dilution

Product Specifications

Product Specific Information

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. Antibody DNA sequences from immunoreactive rabbits are cloned and screened to select optimal candidates for production.
Advantages include:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broader immunoreactivity due to larger rabbit immune repertoire

This antibody has specificity for Human CD31/PECAM1.

Target Information

CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T and B cell signaling via immunoreceptor tyrosine-based inhibitory motifs (ITIM). Upon phosphorylation, these motifs provide docking sites for protein-tyrosine phosphatases.
CD31 is widely expressed within the vascular compartment, mainly at junctions between adjacent cells. Its N-terminal Ig-like domain mediates homophilic binding, crucial for cell-cell interactions.
Functions include:

• Modulation of integrin-mediated adhesion
• Transendothelial migration
• Angiogenesis and apoptosis
• Negative regulation of immunoreceptor signaling
• Roles in autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis, and thrombosis

CD31 is a key regulatory molecule in the vascular system.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.