Thermo Fisher Scientific DNMT3B Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:5,000

Product Specifications

Product Specific Information

• PA1-9542 detects DNMT3L in human samples.
• Successfully used in Western blot procedures.
• Detects a 47 kDa protein representing DNMT3L.
• Immunogen: purified recombinant DNMT3L.1 corresponding to the chromosome 21 gene (Human).

Target Information

CpG methylation is an epigenetic modification important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have shown that DNA methylation is essential for mammalian development.
This gene encodes a DNA methyltransferase functioning in de novo methylation, rather than maintenance methylation. The protein localizes mainly to the nucleus and is developmentally regulated.
Mutations in this gene cause immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome.
Six alternatively spliced transcript variants have been described, with full-length sequences of variants 4 and 5 yet to be determined.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.