Thermo Fisher Scientific DNMT3B Polyclonal Antibody
DNMT3B 단백질을 인식하는 Thermo Fisher Scientific의 Chicken Polyclonal Antibody. 인간 시료에서 Western blot에 최적화. 1 mg/mL 농도의 액상 형태로 제공되며, PBS와 sodium azide 포함. 단기 4°C, 장기 -20°C 보관 권장.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:5,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Chicken / IgY |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Purified recombinant DNMT3L.1 corresponding to the chromosome 21 gene (Human) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | IgY fraction |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2261822 |
Product Specific Information
- PA1-9542 detects DNMT3L in human samples.
- Successfully used in Western blot procedures.
- Detects a 47 kDa protein representing DNMT3L.
- Immunogen: purified recombinant DNMT3L.1 corresponding to the chromosome 21 gene (Human).
Target Information
CpG methylation is an epigenetic modification important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have shown that DNA methylation is essential for mammalian development.
This gene encodes a DNA methyltransferase functioning in de novo methylation, rather than maintenance methylation. The protein localizes mainly to the nucleus and is developmentally regulated.
Mutations in this gene cause immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome.
Six alternatively spliced transcript variants have been described, with full-length sequences of variants 4 and 5 yet to be determined.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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