Thermo Fisher Scientific Perforin Monoclonal Antibody (CE2.10)

Applications

Western Blot (WB)

• Tested Dilution: 1 µg/mL

Immunoprecipitation (IP)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

MA1-25835 detects a band of approximately 66 kDa from the mouse T cell clone B6.1 (positive control).
This antibody does not detect human perforin by western blot.

Target Information

Perforin is a major cytolytic protein found in cytolytic granules. It acts as a pore-forming protein involved in immune defense against tumors and viral infections, mediated by cytotoxic lymphocytes.
Perforin consists of 555 amino acids with a 21 amino acid signal peptide and has a molecular weight of 70–75 kDa. It shares structural similarities with complement component C9.
Expression of perforin is restricted to killer cell lines and absent in helper T cells or other tumor cells.
Defects in the perforin gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare autosomal recessive disorder of early childhood.
Alternative splicing results in multiple transcript variants of perforin.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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