Thermo Fisher Scientific RIP3 Monoclonal Antibody (Rippy-3)
인간 RIP3 단백질을 인식하는 단클론 항체로, Western blot에 최적화됨. 마우스 IgG1 형식으로 제작되어 높은 특이성과 재현성을 제공. 비결합형 액상 제품으로 1 mg/mL 농도, PBS와 sodium azide 포함. 연구용으로만 사용 가능.
- 카탈로그번호
- MA125841
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific RIP3 Monoclonal Antibody (Rippy-3)
Applications
- Western Blot (WB)
Tested Dilution: 1:1,000
Publications: - [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | Rippy-3 |
| Immunogen | Recombinant human RIP3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Purified |
| Storage Buffer | PBS |
| Contains | 0.02% Sodium Azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic), Wet ice (international) |
| RRID | AB_795347 |
Product Specific Information
Predicted molecular weight of MA1-25841 is 62 kDa.
Target Information
RIPK3 is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, featuring a unique C-terminal domain distinct from other RIP family members.
RIPK3 is mainly localized in the cytoplasm and mitochondria, capable of nucleocytoplasmic shuttling via novel nuclear localization and export signals.
It is part of the tumor necrosis factor (TNF) receptor-I signaling complex and can induce apoptosis and weakly activate NF-κB transcription factor. Caspase-8 prevents RIPK3-dependent necrosis by forming a proteolytically active complex with CFLAR, which is essential for its protective function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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