Thermo Fisher Scientific Phospho-E-cadherin (Tyr754) Polyclonal Antibody
E-cadherin Tyr754 인산화 형태를 특이적으로 검출하는 Rabbit Polyclonal Antibody. Western blot 및 IHC(P) 적용 가능. 인간, 마우스, 랫트 반응성. 고순도, 1 mg/mL 농도, -20°C 보관.
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Thermo Fisher Scientific Phospho-E-cadherin (Tyr754) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CDH1 (Accession P12830), corresponding to amino acid residues around phosphorylated Tyr754 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816916 |
Product Specific Information
Antibody detects endogenous levels of E-cadherin only when phosphorylated at Tyr754.
Target Information
E-Cadherin (epithelial cadherin) is a classical cadherin from the calcium-dependent adhesion protein superfamily. It encodes a cell-cell adhesion glycoprotein with five extracellular cadherin repeats, a transmembrane region, and a conserved cytoplasmic tail.
Mutations in CDH1 are associated with various cancers (gastric, breast, colorectal, thyroid, ovarian). Loss of E-cadherin function contributes to cancer progression by promoting proliferation, invasion, and metastasis.
The ectodomain mediates bacterial adhesion to mammalian cells, while the cytoplasmic domain is required for internalization.
E-cadherin plays a central role in maintaining tissue architecture and integrity. In humans, E-cadherin is encoded by the CDH1 gene on chromosome 16.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-105488_E-cadherin_P12830-1_Rabbit.svg, PA5-105488_E-cadherin_P12830-1_Rabbit_PDP.jpeg)
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