Thermo Fisher Scientific Phospho-BCR (Tyr852) Polyclonal Antibody
인산화된 Tyr852 부위의 BCR 단백질을 특이적으로 검출하는 폴리클로날 항체로, Western blot 및 IHC(P) 분석에 적합. 인간, 마우스, 영장류 시료에 반응하며, 고순도의 액상 형태로 제공. 연구용으로만 사용 가능.
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Thermo Fisher Scientific Phospho-BCR (Tyr852) Polyclonal Antibody
Applications and Tested Dilution
- Western Blot (WB): 1:500–1:2,000
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human BCR (Accession P11274), corresponding to amino acid residues around phosphorylated Tyr852 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2816914 |
Product Specific Information
Antibody detects endogenous levels of Bcr only when phosphorylated at Tyr852.
Target Information
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, commonly found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint lies within the BCR gene, resulting in a fusion protein encoded by sequences from both BCR and ABL (chromosome 9).
While the BCR-ABL fusion protein has been well studied, the normal BCR gene product functions as a serine/threonine kinase and a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been identified.
For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.
제품 이미지
(이미지: PA5-105486_Bcr_P11274-1_Rabbit.svg, PA5-105486_Bcr_P11274-1_Rabbit_PDP.jpeg)
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