Thermo Fisher Scientific Phospho-IRAK4 (Thr342) Polyclonal Antibody
IRAK4 단백질의 Thr342 인산화 형태를 특이적으로 인식하는 rabbit polyclonal antibody. Western blot 및 Immunocytochemistry에 사용 가능. 인간 및 생쥐 시료에 반응하며, 액상 형태로 제공. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human IRAK4 (Accession Q9NWZ3), corresponding to amino acid residues around phosphorylated Thr342 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816595 |
Product Specific Information
This antibody detects endogenous levels of IRAK4 only when phosphorylated at Thr342.
Target Information
IL-1 receptor-associated kinases (IRAKs) are serine/threonine kinases involved in signaling via Toll/IL-1 pathways. Overexpression of IRAK4 activates NF-kappa-B and MAPK pathways. IRAK4 interacts with and phosphorylates IRAK1. IRAK4-deficient animals are resistant to LPS challenge, and both animals and humans lacking IRAK4 show impaired responses to viral and bacterial infections. Members of the IRAK/Pelle family play a central role in IL-1R/TLR-mediated inflammatory responses and innate immunity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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