Thermo Fisher Scientific Phospho-LAT (Tyr220) Polyclonal Antibody
LAT 단백질의 Tyr220 인산화 형태를 특이적으로 검출하는 폴리클로날 항체로, Western blot, IHC, ICC/IF에 사용 가능. Rabbit IgG 기반, 1 mg/mL 농도의 액상 시약. 인산화 신호 전달 연구에 적합하며, 인간 및 생쥐 반응성.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human LAT (Accession O43561), corresponding to amino acid residues around phosphorylated Tyr220 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2816597 |
Product Specific Information
Antibody detects endogenous levels of LAT only when phosphorylated at Tyr220, which site historically referenced as Tyr191.
Target Information
LAT (Linker for Activation of T cells) is a 36–38 kDa double-palmitoylated transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells, and platelets. After immunoreceptor triggering, LAT becomes multiply tyrosine-phosphorylated by Syk-, Src-, or Tec-family kinases, providing docking sites for downstream signaling molecules. LAT is essential for TCR-dependent T cell and FcεRI-dependent mast cell activation, as well as for maturation of early thymocytes. It also plays roles in NK cell signaling and platelet activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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