Thermo Fisher Scientific Phospho-IRAK2 (Tyr6) Polyclonal Antibody

Thermo Fisher Scientific Phospho-IRAK2 (Tyr6) Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:2,000 dilution

Product Specifications

Product Specific Information

Antibody detects endogenous levels of IRAK2 only when phosphorylated at Tyr6.

Target Information

IRAK2 (interleukin-1 receptor-associated kinase-like 2) binds to the IL-1 type I receptor following IL-1 engagement and triggers intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
The pro-inflammatory cytokine IL-1 induces cellular response through two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP).
IL-1 receptor-associated kinase (IRAK) mediates activation of NF-kappa-B, a pivotal transcription factor mediating inflammatory and immune response.
A novel member in the IRAK/Pelle family, IRAK2, recruits to the subunits of the IL-1R complex after IL-1 binding and leads to NF-kappa-B activation.
IRAKs also associate with Toll-like receptor (TLR) and dominant negative mutants of IRAKs inhibit LPS-induced NF-kappa-B activation.
Members in the IRAK/Pelle family play a central role in IL-1R and TLR-mediated inflammatory responses to cytokine IL-1 and LPS.
IRAK2 is expressed in a variety of human tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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