Thermo Fisher Scientific C10orf54 Monoclonal Antibody (UMAB272), UltraMAB
인간 C10orf54(VISTA) 단백질을 인식하는 UMAB272 클론 단일클론 항체. 면역조직화학(IHC) 및 ChIP 분석에 적합. 고순도 친화 크로마토그래피 정제, PBS/BSA/글리세롤 버퍼에 보관. 암 면역치료 연구용으로 이상적.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
ChIP assay (ChIP)
- Tested Dilution: Assay-Dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | UMAB272 |
| Immunogen | Full length human recombinant protein of human C10ORF54 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.0 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | −20 °C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
VISTA (V-domain Ig containing suppressor of T-cell activation), also known as B7-H5 or PD-1H, is a product of the VSIR gene.
Although VISTA bears sequence homology to PD-L1, it has a distinct expression pattern.
In both mouse and human, VISTA is predominantly expressed on hematopoietic cells, with the highest densities on myeloid cells and lower levels on T cells. It is typically absent on B cells.
VISTA expressed by antigen-presenting cells directly suppresses proliferation and cytokine production of CD4 and CD8 T cells, making it a promising target for cancer immunotherapy.
Reported ligands include CD28H, VSIG-3, and VSIG-8.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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