Thermo Fisher Scientific COL11A2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.2–1.0 µg/mL

Product Specifications

Product Specific Information

This target displays homology in the following species:

• Cow: 91%
• Dog: 100%
• Human: 100%
• Mouse: 92%
• Pig: 91%
• Rabbit: 92%

Target Information

This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. It is located on chromosome 6 very close to but separate from the gene for retinoid X receptor beta. Type XI collagen is a heterotrimer, and the third alpha chain is a post-translationally modified alpha 1 type II chain. Proteolytic processing of this type XI chain produces PARP, a proline/arginine-rich protein that is an amino terminal domain.
Mutations in this gene are associated with:

• Type III Stickler syndrome
• Otospondylomegaepiphyseal dysplasia (OSMED syndrome)
• Weissenbacher-Zweymuller syndrome
• Autosomal dominant non-syndromic sensorineural type 13 deafness (DFNA13)
• Autosomal recessive non-syndromic sensorineural type 53 deafness (DFNB53)

Alternative splicing results in multiple transcript variants. A related pseudogene is located nearby on chromosome 6.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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