Thermo Fisher Scientific Phospho-PAR4 (Thr163) Polyclonal Antibody
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PAR4 단백질의 Thr163 인산화 부위를 특이적으로 인식하는 rabbit polyclonal antibody. Western blot, IHC, ICC/IF에 사용 가능. 인간, 마우스, 랫트 반응성. 액상 형태로 -20°C 보관. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PAWR (Accession Q96IZ0), corresponding to amino acid residues around phosphorylated Thr163. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816696 |
Product Specific Information
This antibody detects endogenous levels of PAR4 only when phosphorylated at Thr163.
Target Information
This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms.
- Intracellular mechanism: Inhibition of pro-survival pathways and activation of Fas-mediated apoptosis.
- Extracellular mechanism: Binding of secreted protein to glucose regulated protein 78 (GRP78) on the cell surface, leading to activation of the extrinsic apoptotic pathway.
This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated in different tumors. The encoded protein also plays an important role in the progression of age-related diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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