Thermo Fisher Scientific Phospho-SIRT1 (Ser27) Polyclonal Antibody
SIRT1 단백질의 Ser27 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot에 적합하며, 인간 시료에 반응. 액상 형태로 제공되며, PBS/glycerol buffer에 보관. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SIRT1 (Accession Q96EB6), corresponding to amino acid residues around phosphorylated Ser27 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2816695 |
Product Specific Information
This antibody detects endogenous levels of SIRT1 only when phosphorylated at Ser27.
Target Information
NAD-dependent protein deacetylase sirtuin-1 (SIRT1) links transcriptional regulation directly to intracellular energetics and participates in the coordination of several cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis, and autophagy.
SIRT1 modulates chromatin function through deacetylation of histones and can promote alterations in histone and DNA methylation, leading to transcriptional repression.
It is essential in skeletal muscle cell differentiation and, in response to low nutrients, mediates the inhibitory effect on skeletal myoblast differentiation involving AMPK and NAMPT.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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배송/결제/교환/반품 안내
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