Thermo Fisher Scientific CDKN2A Monoclonal Antibody (OTI5G9), TrueMAB
CDKN2A 단백질을 인식하는 Mouse Monoclonal Antibody로, Western Blot 및 IHC(Paraffin)에 사용 가능. Human 시료에 반응하며, 1 mg/mL 농도의 액상 형태. Affinity chromatography로 정제되었으며, -20°C에서 보관.
- 카탈로그번호
- TA805405
- 판매단위
- pk
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Applications
- Western Blot (WB): Assay-dependent
- Immunohistochemistry (Paraffin) (IHC (P)): 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5G9 |
| Immunogen | Full length human recombinant protein of human CDKN2A produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
This gene generates several transcript variants differing in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode isoforms functioning as inhibitors of CDK4 kinase.
Another transcript includes an alternate first exon located 20 Kb upstream, encoding an alternate open reading frame (ARF) that produces a structurally unrelated protein.
The ARF product stabilizes tumor suppressor protein p53 by interacting with and sequestering MDM2, an E3 ubiquitin-protein ligase responsible for p53 degradation.
Despite structural and functional differences, both CDK inhibitor isoforms and the ARF product share a role in cell cycle G1 control through regulation of CDK4 and p53.
This gene is frequently mutated or deleted in various tumors and acts as an important tumor suppressor gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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