Thermo Fisher Scientific p53 Monoclonal Antibody (OTI6C1), TrueMAB
p53 단백질을 인식하는 마우스 단클론 항체로, Western blot에 최적화되어 있습니다. 인간 시료에 반응하며, 액상 형태로 1 mg/mL 농도로 제공됩니다. 세포 스트레스 반응 및 종양 억제 연구에 적합합니다.
- 판매단위
- pk
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Applications
- Western Blot (WB): 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6C1 |
| Immunogen | Full length human recombinant protein of human TP53 produced in SF9 cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
The tumor suppressor protein p53 is a sequence-specific transcription factor activated by cellular stress. It mediates cell cycle arrest or apoptosis in response to DNA damage or nutrient deprivation. p53 upregulates transcription of genes such as p21waf1, leading to G1 or G2/M arrest.
The p53 structure includes:
- N-terminal transactivation domain
- Central DNA-binding domain
- Oligomerization domain
- C-terminal regulatory domain
Phosphorylation at Ser15 is critical for activation and stabilization of p53. Phosphorylation at Ser392 has been associated with tumor formation. p53 plays roles in tumor suppression, aging, and oxidative stress response. Mutations in the TP53 gene are common in human cancers and can lead to loss of tumor suppressor function. Germline mutations in TP53 are linked to Li-Fraumeni syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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