Thermo Fisher Scientific CDKN2A (p16INK4a) Monoclonal Antibody (OTI8E9), TrueMAB
CDKN2A (p16INK4a) 단백질을 인식하는 Mouse Monoclonal Antibody로, Western blot에 적합합니다. Human 시료에 반응하며, Affinity chromatography로 정제되었습니다. 액상 형태로 제공되며, -20°C에서 보관합니다. 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB): 1:200–1:1,000 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI8E9 |
| Immunogen | Full length human recombinant protein of human CDKN2A produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The CDKN2A gene produces multiple transcript variants differing in their first exons. Two variants encode isoforms that act as inhibitors of CDK4 kinase, while another variant encodes an alternate open reading frame (ARF) protein that stabilizes p53 by interacting with MDM2, preventing p53 degradation. Despite structural differences, both CDK inhibitor isoforms and the ARF product regulate cell cycle G1 progression, contributing to tumor suppression. Mutations or deletions in this gene are frequently observed in various tumors, signifying its importance as a tumor suppressor gene.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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