Thermo Fisher Scientific BTK Recombinant Rabbit Monoclonal Antibody (ARC0485)
BTK 단백질을 표적으로 하는 Thermo Fisher Scientific의 재조합 토끼 단클론 항체. Western blot, IHC, ICC/IF, ELISA 등 다양한 응용에 적합. 인간 및 생쥐 반응성. 고순도 친화 크로마토그래피 정제 및 안정한 PBS/glycerol 보존.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:800 |
| Immunocytochemistry (ICC/IF) | 1:100–1:400 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC0485 |
| Immunogen | Synthetic peptide corresponding to amino acids 560–659 of human BTK (Q06187) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849096 |
Product Specific Information
Immunogen sequence:
PVRWSPPEVL MYSKFSSKSD IWAFGVLMWE IYSLGKMPYE RFTNSETAEH IAQGLRLYRP HLASEKVYTI MYSCWHEKAD ERPTFKILLS NILDVMDEES
Target Information
Bruton tyrosine kinase (BTK) is a cytoplasmic tyrosine kinase belonging to the SRC-related TEC subfamily of tyrosine kinases. Mutations in the BTK gene have been linked to severe developmental blocks in human B-cell ontogeny and immunodeficiency disorders. It interacts with members of the toll-like receptor (TLR) family such as TLR4, 6, 8, and 9, which play crucial roles in innate and adaptive immunity. BTK also interacts with MyD88, TIRAP, and IRAK, but not TRAF-6, suggesting its involvement in lipopolysaccharide signal transduction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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